| Active substance |
Leflunomide |
| Also known as |
Arava |
| Blood pressure |
Can cause hypertension |
| Chemical name |
5-methylisoxazole-4-carboxylic acid 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)butylamide |
| Dosage (medical) |
Typically 100 mg daily for three days, then reduced to 10-20 mg daily |
| Dosage (sports) |
Not applicable |
| Effects |
Reduces inflammation and slows disease progression in rheumatoid arthritis and psoriatic arthritis |
| Formula |
C12H9F3N2O2 |
| Half-life |
Approximately 14-18 days |
| Hepatotoxicity |
Yes, potential for significant liver injury, requires regular liver function tests |
| Lab Test |
Liver function tests, complete blood count |
| Main action |
Inhibits the mitochondrial enzyme dihydroorotate dehydrogenase, leading to a reduction in pyrimidine synthesis and modulation of the immune system |
| Side effects |
Diarrhea, respiratory infections, hair loss, rash, hypertension, and liver toxicity |
| Storage conditions |
Store at room temperature away from moisture and heat |
| Strength |
20 mg |
| Substance class |
Disease-modifying antirheumatic drug (DMARD) |
| Trade name |
Arava |
| Use in sports |
None, as it is not performance-enhancing |
| Water Retention |
Minimal to none |
| Manufacturer |
Torrent Pharmaceuticals Ltd. |
| Packing |
10 tabs/blister |
